Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | CDC25A | P30304 | 2/20 | 0.36 |
| ▸ | CDC25B | P30305 | 2/20 | 0.36 |
| ▸ | CDC25C | P30307 | 2/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13028335 | 0.87 | MET (0.57) | METCDK5CDK5R1KDRMEN1 | |
| SCHEMBL16090314 | 0.85 | MET (0.52) | METCDK5CDK5R1KDRMEN1 | |
| SCHEMBL16090380 | 0.83 | MET (0.48) | METCDK5CDK5R1IDH1KDR | |
| SCHEMBL16090384 | 0.81 | MET (0.54) | METCDK5CDK5R1KDRMEN1 | |
| SCHEMBL16090243 | 0.81 | MET (0.48) | METCDK5CDK5R1IDH1KDR | |
| SCHEMBL13028336 | 0.80 | MET (0.52) | METCDK5CDK5R1KDRMEN1 | |
| SCHEMBL16090350 | 0.77 | KDR (0.57) | METKDRMEN1KMT2ACCNE1 | |
| SCHEMBL146175 | 0.77 | MET (0.54) | METKDRMEN1KMT2ACCNE1 | |
| SCHEMBL13028333 | 0.76 | MET (0.57) | METKDRMEN1KMT2ACCNE1 | |
| SCHEMBL16091166 | 0.74 | MET (0.60) | METKDRMEN1KMT2ACCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3037419-A1 | COMPOSITIONS OF KINASE INHIBITORS AND THEIR USE FOR TREATMENT OF CANCER AND OTHER DISEASES RELATED TO KINASES | Boston Biomedical, Inc. (US) | 2016-06-29 | — | — | EP | disclosed |