Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | GRK5 | P34947 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.47 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.47 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.47 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.47 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ABL2 | P42684 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | PRKCB | P05771 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | PRKCH | P24723 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17866059 | 0.86 | NAE1 (0.51) | NAE1CA2GRK5CSNK1A1UBA6 | |
| SCHEMBL17875199 | 0.84 | NAE1 (0.63) | NAE1CA2GRK5CSNK1A1UBA6 | |
| SCHEMBL17875185 | 0.84 | NAE1 (0.63) | NAE1CA2GRK5CSNK1A1UBA6 | |
| SCHEMBL10004920 | 0.81 | NAE1 (0.59) | NAE1CA2GRK5CSNK1A1UBA6 | |
| SCHEMBL10004923 | 0.80 | NAE1 (0.51) | NAE1CA2GRK5CSNK1A1UBA6 | |
| SCHEMBL192900 | 0.79 | NAE1 (0.78) | NAE1CA2GRK5CSNK1A1UBA6 | |
| SCHEMBL18859878 | 0.79 | NAE1 (0.78) | NAE1CA2GRK5CSNK1A1UBA6 | |
| SCHEMBL17875203 | 0.76 | PRMT5 (0.47) | NAE1CA2GRK5CSNK1A1ABL1 | |
| SCHEMBL193487 | 0.74 | NAE1 (0.72) | NAE1CA2GRK5CSNK1A1UBA6 | |
| SCHEMBL193489 | 0.74 | NAE1 (0.72) | NAE1CA2GRK5CSNK1A1UBA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-B1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARM INC (US) | 2016-06-29 | — | — | EP | disclosed |