Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 12/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 10/20 | 0.47 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.46 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ABL2 | P42684 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | PRKCG | P05129 | 1/20 | 0.39 |
| ▸ | PRKCB | P05771 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | PRKCH | P24723 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.39 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10293822 | 0.86 | PIP4K2A (0.49) | PRMT5WDR77YTHDC1PIP4K2ACA2 | |
| SCHEMBL25048531 | 0.86 | YTHDC1 (0.47) | PRMT5WDR77YTHDC1PIP4K2ACA2 | |
| SCHEMBL23892256 | 0.81 | PIP4K2A (0.43) | PRMT5WDR77YTHDC1PIP4K2AADORA3 | |
| SCHEMBL18571707 | 0.80 | ABL1 (0.44) | PRMT5WDR77PIP4K2AABL1EGFR | |
| SCHEMBL17866040 | 0.80 | PRMT5 (0.45) | PRMT5WDR77YTHDC1PIP4K2AADORA3 | |
| SCHEMBL25046637 | 0.77 | PRMT5 (0.39) | PRMT5WDR77YTHDC1PIP4K2AADORA3 | |
| SCHEMBL17875185 | 0.77 | NAE1 (0.63) | EGFRCA2NAE1GRK5CSNK1A1 | |
| SCHEMBL17875199 | 0.77 | NAE1 (0.63) | EGFRCA2NAE1GRK5CSNK1A1 | |
| SCHEMBL25047716 | 0.76 | PIP4K2A (0.42) | PRMT5WDR77YTHDC1PIP4K2ACA2 | |
| SCHEMBL17875188 | 0.76 | NAE1 (0.47) | PRMT5WDR77PIP4K2AABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-B1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARM INC (US) | 2016-06-29 | — | — | EP | disclosed |