Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 7/20 | 0.51 |
| ▸ | UBA3 | Q8TBC4 | 6/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | GRK5 | P34947 | 1/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.51 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.51 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.51 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.51 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.40 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL192044 | 0.86 | NAE1 (0.68) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL17865955 | 0.81 | NAE1 (0.51) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL192175 | 0.77 | NAE1 (0.62) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL18872641 | 0.77 | NAE1 (0.54) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL191182 | 0.76 | NAE1 (0.61) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL17865952 | 0.76 | KDM4E (0.48) | KDM4ETSHRMAPK10HSD17B10PRMT5 | |
| SCHEMBL193225 | 0.75 | NAE1 (0.59) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL12985195 | 0.75 | NAE1 (0.61) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL191135 | 0.75 | NAE1 (0.61) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL17865956 | 0.74 | NAE1 (0.43) | NAE1UBA3CA2GRK5CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-B1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARM INC (US) | 2016-06-29 | — | — | EP | disclosed |