Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.45 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | GALR3 | O60755 | 2/20 | 0.44 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 3/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17865954 | 0.81 | ADK (0.46) | KDM4EHSD17B10TSHRMAPK10HTT | |
| SCHEMBL17865990 | 0.80 | SLC29A1 (0.57) | KDM4EHTTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL17865955 | 0.76 | NAE1 (0.51) | KDM4EHSD17B10TSHRMAPK10HTT | |
| SCHEMBL22400280 | 0.76 | NAE1 (0.61) | EGFR | |
| SCHEMBL17865956 | 0.76 | NAE1 (0.43) | KDM4EHSD17B10TSHRMAPK10HTT | |
| SCHEMBL17875196 | 0.76 | NAE1 (0.51) | KDM4EHSD17B10TSHRMAPK10HTT | |
| SCHEMBL18727734 | 0.75 | ADK (0.48) | ADKPRMT5 | |
| SCHEMBL16414565 | 0.75 | PRMT5 (0.43) | PRMT5 | |
| SCHEMBL27739697 | 0.75 | PRMT5 (0.43) | PRMT5 | |
| SCHEMBL192044 | 0.74 | NAE1 (0.68) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-B1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARM INC (US) | 2016-06-29 | — | — | EP | claimed |