SCHEMBL17875309

SCHEMBL17875309

c1cnc(-n2ccc3cc(N4CCOc5ncnc6c5C4=N6)cnc32)cn1

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 19/20 0.51
HPGD P15428 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17875317 0.85 DGAT1 (0.56) DGAT1
SCHEMBL17875337 0.83 DGAT1 (0.54) DGAT1
SCHEMBL17875331 0.83 DGAT1 (0.49) DGAT1
SCHEMBL14061911 0.83 DGAT1 (0.74) DGAT1
SCHEMBL17875313 0.83 DGAT1 (0.54) DGAT1
SCHEMBL17875333 0.82 DGAT1 (0.55) DGAT1
SCHEMBL17875316 0.81 DGAT1 (0.61) DGAT1HPGD
SCHEMBL17875314 0.79 DGAT1 (0.47) DGAT1
SCHEMBL17875320 0.79 DGAT1 (0.57) DGAT1
SCHEMBL17875319 0.78 DGAT1 (0.53) DGAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2710013-B1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE IP NO 2 LTD (GB) 2016-06-29 EP disclosed