Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 9/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.54 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MLYCD | O95822 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9188069 | 0.91 | HSP90AA1 (0.62) | HPGDTDP1LMNAMEN1KMT2A | |
| SCHEMBL7321474 | 0.84 | HSP90AA1 (0.56) | HPGDTDP1LMNAMEN1KMT2A | |
| SCHEMBL14052528 | 0.84 | HPGD (0.64) | HPGDTDP1LMNASMN1; SMN2HSP90AA1 | |
| SCHEMBL471665 | 0.84 | HPGD (0.72) | HPGDTDP1LMNAMEN1KMT2A | |
| SCHEMBL7314304 | 0.83 | HSP90AA1 (0.54) | HPGDTDP1LMNAMEN1KMT2A | |
| SCHEMBL11282231 | 0.82 | HSP90AA1 (0.66) | HPGDTDP1LMNAMEN1KMT2A | |
| SCHEMBL18050288 | 0.78 | HPGD (0.56) | HPGDTDP1LMNAMEN1KMT2A | |
| SCHEMBL4545228 | 0.77 | HSP90AA1 (0.70) | HPGDTDP1LMNAMEN1KMT2A | |
| SCHEMBL18661938 | 0.77 | HPGD (0.68) | HPGDTDP1LMNAMEN1KMT2A | |
| SCHEMBL5703500 | 0.77 | HPGD (0.73) | HPGDTDP1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180065976-A1 | DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS | WILLIAM MARSH RICE UNIVERSITY (US) | 2018-03-08 | — | — | US | disclosed |
| US-9777013-B2 | Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents | WILLIAM MARSH RICE UNIVERSITY (US) | 2017-10-03 | — | — | US | disclosed |
| US-20160185791-A1 | DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS | WILLIAM MARSH RICE UNIVERSITY (US) | 2016-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160185791-A1 | DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS | UNC119, UNC93B1, RIOX2 | HPGD 3834/4885TDP1 3212/4885LMNA 3326/4885 |
| US-20180065976-A1 | DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS | UNC119, UNC93B1, RIOX2 | HPGD 3667/4885TDP1 2198/4885LMNA 3051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.