Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.48 |
| ▸ | KLK1 | P06870 | 2/20 | 0.48 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.44 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.44 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.44 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.44 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.44 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1787838 | 1.00 | HRH3 (0.49) | HRH3ALDH1A1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL1788393 | 1.00 | HRH3 (0.49) | HRH3ALDH1A1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL1792073 | 0.92 | HRH3 (0.50) | HRH3ALDH1A1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL1791917 | 0.90 | HRH3 (0.53) | HRH3ALDH1A1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL1788640 | 0.90 | HRH3 (0.45) | HRH3KLKB1KLK1CXCR3PRKAB2 | |
| SCHEMBL1787507 | 0.90 | HRH3 (0.45) | HRH3KLKB1KLK1CXCR3PRKAB2 | |
| SCHEMBL1787502 | 0.90 | HRH3 (0.45) | HRH3KLKB1KLK1CXCR3PRKAB2 | |
| SCHEMBL1786878 | 0.89 | KLKB1 (0.46) | HRH3ALDH1A1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL1787879 | 0.89 | KLKB1 (0.46) | HRH3ALDH1A1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL1786875 | 0.89 | KLKB1 (0.46) | HRH3ALDH1A1RAB9ASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110124626-A1 | BENZAZEPINE DERIVATIVES AND THEIR USE AS HISTAMINE H3 ANTAGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110124626-A1 | BENZAZEPINE DERIVATIVES AND THEIR USE AS HISTAMINE H3 ANTAGONISTS | HRH4, HRH3, HRH2 | HRH3 2/4885ALDH1A1 1526/4885RAB9A 2688/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.