Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.43 |
| ▸ | MEN1 | O00255 | 8/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | DDX3X | O00571 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17877915 | 0.89 | MEN1 (0.46) | SMN1; SMN2KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL17878748 | 0.86 | MAPT (0.43) | SMN1; SMN2KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL17878874 | 0.83 | MEN1 (0.44) | SMN1; SMN2KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL17878694 | 0.78 | MAPT (0.41) | SMN1; SMN2KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL17878865 | 0.75 | NR1H2 (0.38) | SMN1; SMN2ALDH1A1LMNANPSR1 | |
| SCHEMBL15273052 | 0.73 | KMT2A (0.58) | SMN1; SMN2KMT2AMEN1MAPTHTT | |
| SCHEMBL32660723 | 0.72 | KMT2A (0.64) | SMN1; SMN2KMT2AMEN1MAPTHTT | |
| SCHEMBL31135773 | 0.72 | SMN1; SMN2 (0.64) | SMN1; SMN2SIRT2KMT2AMEN1MAPT | |
| SCHEMBL3222110 | 0.72 | SMN1; SMN2 (0.64) | SMN1; SMN2SIRT2KMT2AMEN1MAPT | |
| SCHEMBL14546312 | 0.72 | NR1H2 (0.33) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016105528-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-06-30 | — | — | WO | disclosed |