Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17878694 | 0.91 | MAPT (0.41) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL17878874 | 0.89 | MEN1 (0.44) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL17878865 | 0.88 | NR1H2 (0.38) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL17878730 | 0.86 | SMN1; SMN2 (0.44) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL17877915 | 0.82 | MEN1 (0.46) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL17872129 | 0.73 | KMT2A (0.43) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL17878721 | 0.72 | MAPT (0.41) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL17878628 | 0.72 | MAPT (0.41) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL17872158 | 0.72 | KMT2A (0.43) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL17872164 | 0.72 | NTRK1 (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016105528-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-06-30 | — | — | WO | disclosed |