Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 13/20 | 0.71 |
| ▸ | MDM4 | O15151 | 10/20 | 0.71 |
| ▸ | EIF4E | P06730 | 1/20 | 0.56 |
| ▸ | EIF4EBP1 | Q13541 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 4/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.54 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.52 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17880430 | 0.92 | MDM2 (0.78) | MDM2MDM4EIF4EEIF4EBP1ESR1 | |
| SCHEMBL17884324 | 0.87 | MDM2 (0.71) | MDM2MDM4EIF4EEIF4EBP1PCSK9 | |
| SCHEMBL29468183 | 0.80 | MDM2 (0.93) | MDM2MDM4PCSK9 | |
| SCHEMBL17880418 | 0.80 | MDM2 (0.54) | MDM2MDM4EIF4EEIF4EBP1ESR1 | |
| SCHEMBL15183813 | 0.79 | MDM2 (0.66) | MDM2MDM4EIF4EEIF4EBP1ESR1 | |
| SCHEMBL19406734 | 0.75 | MDM2 (0.67) | MDM2MDM4EIF4EEIF4EBP1PCSK9 | |
| SCHEMBL16167598 | 0.74 | MDM2 (0.68) | MDM2MDM4EIF4EEIF4EBP1ESR1 | |
| SCHEMBL29972035 | 0.74 | MDM2 (0.72) | MDM2MDM4ESR1ESR2PCSK9 | |
| SCHEMBL12297512 | 0.73 | MDM2 (0.58) | MDM2MDM4EIF4EEIF4EBP1ESR1 | |
| SCHEMBL12297508 | 0.73 | MDM2 (0.58) | MDM2MDM4EIF4EEIF4EBP1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160185821-A1 | Z-SELECTIVE OLEFIN METATHESIS OF PEPTIDES | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2016-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160185821-A1 | Z-SELECTIVE OLEFIN METATHESIS OF PEPTIDES | QPCT, PTMS, MAX | MDM2 473/4885MDM4 641/4885EIF4E 2518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.