Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL58561 | 0.81 | TSHR (0.49) | TSHRNPSR1RXFP1SLC9A1KEAP1 | |
| Fluoride SCHEMBL6346 | 0.80 | TSHR (0.47) | TSHRNPSR1RXFP1SLC9A1KEAP1 | |
| SCHEMBL936121 | 0.77 | TSHR (0.44) | TSHRNPSR1RXFP1SLC9A1KEAP1 | |
| SCHEMBL20021609 | 0.77 | TSHR (0.44) | TSHRNPSR1RXFP1SLC9A1KEAP1 | |
| Fluoride SCHEMBL29274482 | 0.75 | TSHR (0.43) | TSHRNPSR1RXFP1SLC9A1KEAP1 | |
| Phosphoric Acid SCHEMBL19406123 | 0.73 | HDAC3 (0.42) | TSHRNPSR1RXFP1SLC9A1KEAP1 | |
| SCHEMBL433711 | 0.73 | TSHR (0.50) | TSHRNPSR1RXFP1SLC9A1KEAP1 | |
| SCHEMBL16497703 | 0.73 | TSHR (0.53) | TSHRNPSR1RXFP1SLC9A1KEAP1 | |
| SCHEMBL448453 | 0.72 | HDAC3 (0.41) | TSHRNPSR1RXFP1SLC9A1KEAP1 | |
| SCHEMBL16004772 | 0.72 | TSHR (0.49) | TSHRNPSR1RXFP1SLC9A1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9593113-B2 | Imide and acylurea derivatives as modulators of the glucocorticoid receptor | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-14 | — | — | US | disclosed |
| US-9593113-B2 | Imide and acylurea derivatives as modulators of the glucocorticoid receptor | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-14 | — | — | US | disclosed |
| US-20160185776-A1 | IMIDE AND ACYLUREA DERIVATIVES AS MODULATORS OF THE GLUCOCORTICOID RECEPTOR | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160185776-A1 | IMIDE AND ACYLUREA DERIVATIVES AS MODULATORS OF THE GLUCOCORTICOID RECEPTOR | NFKBIA, IKBKB, NFRKB | TSHR 778/4885NPSR1 2783/4885RXFP1 3854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.