Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TSPO | P30536 | 1/20 | 0.31 |
| ▸ | EDNRB | P24530 | 1/20 | 0.31 |
| ▸ | EDNRA | P25101 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20392246 | 0.95 | KDM4E (0.41) | KDM4EATML3MBTL1ALOX5BACE1 | |
| SCHEMBL16545686 | 0.95 | KDM4E (0.45) | KDM4EATML3MBTL1ALOX5BACE1 | |
| SCHEMBL22112883 | 0.95 | KDM4E (0.47) | KDM4EATML3MBTL1ALOX5BACE1 | |
| SCHEMBL24173861 | 0.94 | KDM4E (0.41) | KDM4EATML3MBTL1ALOX5BACE1 | |
| SCHEMBL17885336 | 0.94 | KDM4E (0.37) | KDM4EATML3MBTL1ALOX5BACE1 | |
| SCHEMBL16804064 | 0.94 | KDM4E (0.44) | KDM4EATML3MBTL1ALOX5BACE1 | |
| SCHEMBL25674933 | 0.94 | L3MBTL1 (0.39) | KDM4EATML3MBTL1ALOX5BACE1 | |
| SCHEMBL18779519 | 0.94 | KDM4E (0.46) | KDM4EATML3MBTL1ALOX5BACE1 | |
| SCHEMBL20715122 | 0.93 | BACE1 (0.36) | KDM4EATML3MBTL1ALOX5BACE1 | |
| SCHEMBL19106717 | 0.93 | KDM4E (0.46) | KDM4EATML3MBTL1ALOX5BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237409-B1 | CARBAZOLES WITH TWO DIBENZOFURAN OR DIBENZOTHIOPHENE SUBSTITUENTS | MERCK PATENT GMBH (DE) | 2022-01-05 | — | — | EP | disclosed |
| US-20190044071-A1 | CARBAZOLES WITH TWO DIBENZOFURAN OR DIBENZOTHIOPHENE SUBSTITUENTS | MERCK PATENT GMBH (DE) | 2019-02-07 | — | — | US | disclosed |
| WO-2016102040-A1 | CARBAZOLES WITH TWO DIBENZOFURAN OR DIBENZOTHIOPHENE SUBSTITUENTS | MERCK PATENT GMBH (DE) | 2016-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190044071-A1 | CARBAZOLES WITH TWO DIBENZOFURAN OR DIBENZOTHIOPHENE SUBSTITUENTS | BRD3, BRPF3, DDT | KDM4E 2631/4885ATM 3655/4885L3MBTL1 638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.