Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 4/20 | 0.59 |
| ▸ | HTR2C | P28335 | 6/20 | 0.48 |
| ▸ | HTR2B | P41595 | 6/20 | 0.48 |
| ▸ | HTR2A | P28223 | 5/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.40 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29427088 | 0.77 | KDM1A (0.50) | KDM1AHTR2CHTR2BHTR2ASLC6A2 | |
| SCHEMBL10046437 | 0.77 | KDM1A (0.50) | KDM1AHTR2CHTR2BHTR2ASLC6A2 | |
| SCHEMBL15096162 | 0.76 | KDM1A (0.96) | KDM1AHTR2CHTR2BHTR2ASLC6A2 | |
| SCHEMBL19781088 | 0.75 | TP53 (0.47) | KDM1AHTR2CHTR2BHTR2ASLC6A2 | |
| SCHEMBL15540897 | 0.74 | KDM1A (0.61) | KDM1AHTR2CHTR2BRCOR1KDM1B | |
| Hydrochloric Acid SCHEMBL17766532 | 0.74 | KDM1A (1.00) | KDM1AHTR2CHTR2BHTR2ASLC6A2 | |
| SCHEMBL28571106 | 0.74 | BRD4 (0.56) | KDM1AHTR2CHTR2BHTR2ASLC6A2 | |
| Hydrochloric Acid SCHEMBL16340197 | 0.74 | KDM1A (1.00) | KDM1AHTR2CHTR2BHTR2ASLC6A2 | |
| Hydrochloric Acid SCHEMBL20187080 | 0.74 | KDM1A (1.00) | KDM1AHTR2CHTR2BHTR2ASLC6A2 | |
| SCHEMBL968177 | 0.73 | KDM1A (0.47) | KDM1AHTR2CHTR2BHTR2ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109501-A1 | AMIDE COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |