Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 4/20 | 0.42 |
| ▸ | HTR2B | P41595 | 4/20 | 0.42 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL971145 | 0.86 | KDM1A (0.40) | KDM1ABRD4HTR2CHTR2BMAP1LC3B | |
| SCHEMBL29427088 | 0.80 | KDM1A (0.50) | KDM1ABRD4HTR2CHTR2BMAP1LC3B | |
| SCHEMBL10046437 | 0.80 | KDM1A (0.50) | KDM1ABRD4HTR2CHTR2BMAP1LC3B | |
| SCHEMBL2530746 | 0.74 | KDM1A (0.45) | KDM1ABRD4HTR2CHTR2BMAP1LC3B | |
| SCHEMBL30626968 | 0.74 | KDM1A (0.45) | KDM1ABRD4HTR2CHTR2BMAP1LC3B | |
| SCHEMBL23380370 | 0.74 | HTR2C (0.46) | KDM1ABRD4HTR2CHTR2BMAP1LC3B | |
| SCHEMBL28571106 | 0.73 | BRD4 (0.56) | KDM1ABRD4HTR2CHTR2BMAP1LC3B | |
| SCHEMBL17892133 | 0.73 | KDM1A (0.59) | KDM1ABRD4HTR2CHTR2BMAP1LC3B | |
| SCHEMBL9614433 | 0.71 | MEN1 (0.42) | HTR2CHTR2BSLC6A2HTR2ASLC6A4 | |
| SCHEMBL5584663 | 0.71 | KDM1A (0.42) | KDM1ABRD4HTR2CHTR2BMAP1LC3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451793-B1 | BACE INHIBITORS | LILLY CO ELI (US) | 2016-11-02 | — | — | EP | disclosed |
| US-20120323001-A1 | BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2012-12-20 | — | — | US | disclosed |
| US-8278441-B2 | BACE inhibitors | ELI LILLY AND COMPANY (US) | 2012-10-02 | — | — | US | disclosed |
| US-20110009395-A1 | BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120323001-A1 | BACE INHIBITORS | BACE1, BACE2, APP | KDM1A 1158/4885BRD4 560/4885HTR2C 4531/4885 |
| US-20110009395-A1 | BACE INHIBITORS | BACE1, BACE2, APP | KDM1A 1158/4885BRD4 560/4885HTR2C 4531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.