Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 12/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | NMUR2 | Q9GZQ4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17892157 | 1.00 | SLC6A2 (0.60) | SLC6A2SLC6A4SLC6A3CYP2D6CYP3A4 | |
| SCHEMBL17892183 | 0.77 | SMN1; SMN2 (0.46) | SLC6A2SLC6A4SLC6A3CYP2D6SMN1; SMN2 | |
| SCHEMBL1897214 | 0.75 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6CYP3A4 | |
| SCHEMBL1903870 | 0.75 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6CYP3A4 | |
| SCHEMBL17455449 | 0.75 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6CYP3A4 | |
| SCHEMBL1898584 | 0.75 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6CYP3A4 | |
| SCHEMBL1903873 | 0.75 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6CYP3A4 | |
| SCHEMBL12004648 | 0.75 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6CYP3A4 | |
| SCHEMBL17455448 | 0.75 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6CYP3A4 | |
| SCHEMBL17892071 | 0.75 | TAAR1 (0.63) | SLC6A2SLC6A4SLC6A3TAAR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109501-A1 | AMIDE COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |
| WO-2016109501-A1 | AMIDE COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |