Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2549352 | 0.83 | CYP1A2 (0.46) | SMN1; SMN2SLC6A2SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL1554808 | 0.77 | BCAT2 (0.51) | SMN1; SMN2SLC6A2SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL17373696 | 0.77 | BCAT2 (0.51) | SMN1; SMN2SLC6A2SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL17892155 | 0.77 | SLC6A2 (0.60) | SMN1; SMN2SLC6A2SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL17892157 | 0.77 | SLC6A2 (0.60) | SMN1; SMN2SLC6A2SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL19692700 | 0.76 | CNR1 (0.42) | SMN1; SMN2SLC6A2SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL2553821 | 0.74 | P4HB (0.42) | KCNA3 | |
| Bromobenzene SCHEMBL27905968 | 0.74 | CYP2C19 (0.63) | SMN1; SMN2CYP1A2ALDH1A1LMNACYP2D6 | |
| SCHEMBL3655014 | 0.72 | MTNR1A (0.58) | SMN1; SMN2SLC6A4ALDH1A1LMNACYP2D6 | |
| SCHEMBL3655009 | 0.72 | MTNR1A (0.58) | SMN1; SMN2SLC6A4ALDH1A1LMNACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109501-A1 | AMIDE COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |