Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.52 |
| ▸ | LCK | P06239 | 4/20 | 0.51 |
| ▸ | ITK | Q08881 | 4/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.51 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PI4KA | P42356 | 1/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | TEC | P42680 | 1/20 | 0.43 |
| ▸ | TXK | P42681 | 1/20 | 0.43 |
| ▸ | BMX | P51813 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13189384 | 0.83 | ABL1 (0.52) | PIK3CDPIK3CGLCKITKAURKB | |
| SCHEMBL138576 | 0.82 | AURKB (0.79) | PIK3CDPIK3CGLCKITKAURKB | |
| SCHEMBL138575 | 0.82 | AURKB (0.79) | PIK3CDPIK3CGLCKITKAURKB | |
| SCHEMBL10081057 | 0.81 | PIK3CG (0.56) | PIK3CDPIK3CGAURKBPIK3CAMEN1 | |
| SCHEMBL10081021 | 0.79 | NPC1 (0.68) | PIK3CDPIK3CGPIK3CAPIP5K1CPIK3CB | |
| SCHEMBL178947 | 0.79 | AURKB (0.49) | PIK3CDPIK3CGLCKITKAURKB | |
| SCHEMBL10080976 | 0.78 | PIK3CD (0.62) | PIK3CDPIK3CGLCKPIK3CAPIP5K1C | |
| SCHEMBL178949 | 0.77 | AURKB (0.54) | PIK3CDPIK3CGLCKITKAURKB | |
| SCHEMBL10080989 | 0.76 | PIK3CD (0.67) | PIK3CDPIK3CGLCKPIK3CAPIP5K1C | |
| SCHEMBL10081070 | 0.76 | PIK3CG (0.64) | PIK3CDPIK3CGPIK3CAPIP5K1CPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058984-A1 | PYRIMIDINE DERIVATIVES USED AS ITK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058984-A1 | PYRIMIDINE DERIVATIVES USED AS ITK INHIBITORS | DTYMK, ITK, DCK | PIK3CD 231/4885PIK3CG 308/4885LCK 189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.