Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17896016 | 0.88 | KDM4E (0.41) | KDM4ERAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL17896029 | 0.88 | CHRM2 (0.46) | KDM4EALDH1A1MEN1KMT2AGLA | |
| SCHEMBL17896020 | 0.87 | CHRM2 (0.53) | KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL17896015 | 0.87 | KDM4E (0.40) | KDM4EALDH1A1MEN1KMT2AGLA | |
| SCHEMBL17895862 | 0.87 | KMT2A (0.40) | KDM4ERAB9AALDH1A1HPGDHTT | |
| SCHEMBL17895999 | 0.86 | HDAC1 (0.43) | KDM4ERAB9AALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL17896038 | 0.86 | CHRM2 (0.52) | KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL17895993 | 0.85 | HDAC1 (0.43) | KDM4EALDH1A1LMNA | |
| Trifluoroacetic Acid SCHEMBL17895987 | 0.83 | CHRM2 (0.42) | KDM4EALDH1A1 | |
| SCHEMBL17896006 | 0.80 | LMNA (0.38) | KDM4ERAB9AALDH1A1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109706-A1 | FUSED POLYCYCLIC 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-07-07 | — | — | WO | claimed |
| WO-2016109706-A1 | FUSED POLYCYCLIC 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |