Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 20/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 11/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17897230 | 0.81 | ADORA2A (0.60) | ADORA2AADORA1KCNH2 | |
| SCHEMBL19003487 | 0.80 | ADORA2A (0.55) | ADORA2AADORA1KCNH2 | |
| SCHEMBL25418864 | 0.79 | ADORA2A (0.59) | ADORA2AADORA1KCNH2 | |
| SCHEMBL30427857 | 0.79 | ADORA2A (0.57) | ADORA2AADORA1KCNH2 | |
| SCHEMBL15845519 | 0.79 | ADORA2A (0.57) | ADORA2AADORA1KCNH2 | |
| SCHEMBL19104715 | 0.79 | ADORA2A (0.59) | ADORA2AADORA1KCNH2 | |
| SCHEMBL30428259 | 0.78 | ADORA2A (0.56) | ADORA2AADORA1KCNH2 | |
| SCHEMBL15845642 | 0.78 | ADORA2A (0.56) | ADORA2AADORA1KCNH2 | |
| SCHEMBL17897199 | 0.78 | ADORA2A (0.64) | ADORA2AADORA1KCNH2 | |
| SCHEMBL17897304 | 0.78 | ADORA2A (0.77) | ADORA2AADORA1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2938344-B1 | PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES | MERCK SHARP & DOHME (US) | 2017-06-21 | — | — | EP | disclosed |
| US-9676780-B2 | Piperazine-substituted [1,2,4]triazolo[1,5-C]quinazolin-5-amine compounds with A2A antagonist properties | MERCK SHARP & DOHME CORP. (US) | 2017-06-13 | — | — | US | disclosed |
| US-20160194330-A1 | PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES | MERCK SHARP & DOHME CORP. (US) | 2016-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160194330-A1 | PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES | ADORA2A, ADORA1, ADORA3 | ADORA2A 1/4885ADORA1 2/4885KCNH2 1014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.