Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTP1 | P09211 | 1/20 | 0.38 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2282073 | 0.75 | GSTP1 (0.43) | GSTP1GSTM2TGFBR1CCNA2CDK2 | |
| SCHEMBL4082004 | 0.72 | GSTP1 (0.49) | GSTP1GSTM2TGFBR1CCNA2CDK2 | |
| SCHEMBL1025073 | 0.72 | F2 (0.43) | GSTP1GSTM2P2RX3 | |
| SCHEMBL1026878 | 0.72 | MELK (0.42) | GSTP1GSTM2P2RX3 | |
| SCHEMBL9176156 | 0.71 | CCNA2 (0.44) | GSTP1GSTM2TGFBR1CCNA2CDK2 | |
| SCHEMBL23500769 | 0.71 | MEN1 (0.54) | GSTP1GSTM2TGFBR1CCNA2CDK2 | |
| SCHEMBL21471527 | 0.71 | GSTP1 (0.51) | GSTP1GSTM2TGFBR1CCNA2CDK2 | |
| SCHEMBL28409562 | 0.71 | GSTP1 (0.51) | GSTP1GSTM2TGFBR1CCNA2CDK2 | |
| SCHEMBL30758555 | 0.70 | GSTP1 (0.45) | GSTP1GSTM2TGFBR1CCNA2CDK2 | |
| SCHEMBL2523198 | 0.70 | TGFBR1 (0.36) | GSTP1GSTM2TGFBR1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10266489-B2 | Pyrrolic amide compound and preparation method and application thereof | HITGEN LTD (CN) | 2019-04-23 | — | — | US | disclosed |
| EP-3241823-B1 | PYRROLE AMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | HITGEN LTD (CN) | 2019-04-17 | — | — | EP | disclosed |
| EP-3241823-A1 | PYRROLE AMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | Hitgen Ltd. (CN) | 2017-11-08 | — | — | EP | disclosed |
| US-20170298016-A1 | PYRROLIC AMIDE COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF | HITGEN INC. (CN) | 2017-10-19 | — | — | US | disclosed |
| WO-2016107542-A1 | PYRROLE AMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | 成都先导药物开发有限公司 | 2016-07-07 | — | — | WO | disclosed |
| WO-2016107541-A1 | PYRROLE AMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | 成都先导药物开发有限公司 | 2016-07-07 | — | — | WO | disclosed |
| WO-2016107227-A1 | PYRROLE AMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | 成都先导药物开发有限公司 | 2016-07-07 | — | — | WO | disclosed |
| WO-2016107544-A1 | INTERMEDIATE COMPOUND FOR PREPARING PYRROLE AMIDE COMPOUND AND PREPARATION METHOD AND USE THEREOF | 成都先导药物开发有限公司 | 2016-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170298016-A1 | PYRROLIC AMIDE COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF | HDAC1, HDAC3, HDAC11 | GSTP1 4312/4885GSTM2 4489/4885TGFBR1 1402/4885 |
| US-10266489-B2 | Pyrrolic amide compound and preparation method and application thereof | HDAC1, HDAC3, HDAC11 | GSTP1 4312/4885GSTM2 4489/4885TGFBR1 1402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.