Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | NAAA | Q02083 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 2/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19091515 | 0.96 | NAAA (0.33) | LRRK2NAAAMERTKAXLBRD4 | |
| SCHEMBL17899008 | 0.94 | NAAA (0.32) | LRRK2NAAACNR1CNR2 | |
| SCHEMBL15373786 | 0.94 | MERTK (0.35) | LRRK2NAAAMERTKAXLCNR2 | |
| SCHEMBL15373812 | 0.94 | MERTK (0.35) | LRRK2NAAAMERTKAXLCNR2 | |
| SCHEMBL15373807 | 0.94 | MERTK (0.35) | LRRK2NAAAMERTKAXLCNR2 | |
| SCHEMBL15616885 | 0.94 | MERTK (0.35) | LRRK2NAAAMERTKAXLCNR2 | |
| SCHEMBL15373801 | 0.94 | MERTK (0.35) | LRRK2NAAAMERTKAXLCNR2 | |
| SCHEMBL15373808 | 0.94 | MERTK (0.35) | LRRK2NAAAMERTKAXLCNR2 | |
| SCHEMBL19628476 | 0.92 | MERTK (0.34) | LRRK2NAAAMERTKAXLBRD4 | |
| SCHEMBL17898760 | 0.91 | NAAA (0.33) | LRRK2NAAAMERTKAXLCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109291-A1 | USE OF MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2016-07-07 | — | — | WO | disclosed |
| WO-2016109290-A1 | MACROCYCLIC PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY | DOW AGROSCIENCES LLC (US) | 2016-07-07 | — | — | WO | disclosed |