Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.91 |
| ▸ | XDH | P47989 | 5/20 | 0.75 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | CASP3 | P42574 | 1/20 | 0.61 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.61 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.61 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17077418 | 0.96 | EGFR (1.00) | EGFRXDHNFE2L2 | |
| SCHEMBL17077420 | 0.96 | EGFR (1.00) | EGFRXDHNFE2L2 | |
| SCHEMBL29857121 | 0.94 | EGFR (0.81) | EGFRXDHNFE2L2CYP1A2NPC1 | |
| SCHEMBL25842295 | 0.93 | EGFR (0.80) | EGFRXDHNFE2L2CYP1A2NPC1 | |
| SCHEMBL14435891 | 0.91 | EGFR (0.76) | EGFRXDHNFE2L2CYP1A2NPC1 | |
| SCHEMBL28582218 | 0.89 | EGFR (0.74) | EGFRXDHNFE2L2CYP1A2NPC1 | |
| SCHEMBL17077332 | 0.89 | EGFR (0.89) | EGFRXDHNFE2L2NPC1RAB9A | |
| SCHEMBL30825572 | 0.89 | EGFR (0.74) | EGFRXDHNFE2L2CYP1A2NPC1 | |
| SCHEMBL1524509 | 0.89 | EGFR (0.74) | EGFRXDHNFE2L2CYP1A2NPC1 | |
| SCHEMBL1524510 | 0.89 | EGFR (0.74) | EGFRXDHNFE2L2CYP1A2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230357200-A1 | SMALL MOLECULE STIMULATORS OF STEROID RECEPTOR COACTIVATOR-3 AND METHODS OF THEIR USE AS CARDIOPROTECTIVE AND/OR VASCULAR REGENERATIVE AGENTS | BAYLOR COLLEGE OF MEDICINE (US) | 2023-11-09 | — | — | US | disclosed |
| US-11708350-B2 | Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents | BAYLOR COLLEGE OF MEDICINE (US) | 2023-07-25 | — | — | US | disclosed |
| US-11325875-B2 | Compound having chiral spirobiindane skeleton and preparation method therefor | ZHEJIANG JIUZHOU PHARM CO LTD (CN) | 2022-05-10 | — | — | US | disclosed |
| US-11312676-B2 | Small molecule stimulators of steroid receptor coactivator proteins and their use in the treatment of cancer | BAYLOR COLLEGE OF MEDICINE (US) | 2022-04-26 | — | — | US | disclosed |
| US-20210115017-A1 | SMALL MOLECULE STIMULATORS OF STEROID RECEPTOR COACTIVATOR-3 AND METHODS OF THEIR USE AS CARDIOPROTECTIVE AND/OR VASCULAR REGENERATIVE AGENTS | BAYLOR COLLEGE OF MEDICINE (US) | 2021-04-22 | — | — | US | disclosed |
| US-10875841-B2 | Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents | BAYLOR COLLEGE OF MEDICINE (US) | 2020-12-29 | — | — | US | disclosed |
| US-20200071300-A1 | Small Molecule Stimulators of Steroid Receptor Coactivator-3 and Methods of Their Use as Cardioprotective and/or Vascular Regenerative Agents | BAYLOR COLLEGE OF MEDICINE (US) | 2020-03-05 | — | — | US | disclosed |
| WO-2017107789-A1 | COMPOUND HAVING CHIRAL SPIROBIINDANE SKELETON AND PREPARATION METHOD THEREFOR | 浙江九洲药业股份有限公司 | 2017-06-29 | — | — | WO | disclosed |
| WO-2016109470-A1 | SMALL MOLECULE STIMULATORS OF STEROID RECEPTOR COACTIVATOR PROTEINS AND THEIR USE IN THE TREATMENT OF CANCER | BAYLOR COLLEGE OF MEDICINE (US) | 2016-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11325875-B2 | Compound having chiral spirobiindane skeleton and preparation method therefor | REN, VKORC1, NR3C2 | EGFR 723/4885XDH 2255/4885NFE2L2 1848/4885 |
| US-20200071300-A1 | Small Molecule Stimulators of Steroid Receptor Coactivator-3 and Methods of Their Use as Cardioprotective and/or Vascular Regenerative Agents | NCOA3, FABP3, NCOA1 | EGFR 2269/4885XDH 3663/4885NFE2L2 1274/4885 |
| US-11312676-B2 | Small molecule stimulators of steroid receptor coactivator proteins and their use in the treatment of cancer | NCOA2, NCOA1, NCOA3 | EGFR 739/4885XDH 3859/4885NFE2L2 1518/4885 |
| US-20210115017-A1 | SMALL MOLECULE STIMULATORS OF STEROID RECEPTOR COACTIVATOR-3 AND METHODS OF THEIR USE AS CARDIOPROTECTIVE AND/OR VASCULAR REGENERATIVE AGENTS | NCOA3, FABP3, NCOA1 | EGFR 2269/4885XDH 3663/4885NFE2L2 1274/4885 |
| US-11708350-B2 | Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents | NCOA3, FABP3, NCOA1 | EGFR 2269/4885XDH 3663/4885NFE2L2 1274/4885 |
| US-10875841-B2 | Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents | NCOA3, FABP3, NCOA1 | EGFR 2269/4885XDH 3663/4885NFE2L2 1274/4885 |
| US-20230357200-A1 | SMALL MOLECULE STIMULATORS OF STEROID RECEPTOR COACTIVATOR-3 AND METHODS OF THEIR USE AS CARDIOPROTECTIVE AND/OR VASCULAR REGENERATIVE AGENTS | NCOA3, FABP3, NCOA1 | EGFR 2269/4885XDH 3663/4885NFE2L2 1274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.