Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.54 |
| ▸ | JAK1 | P23458 | 9/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.52 |
| ▸ | JAK3 | P52333 | 5/20 | 0.51 |
| ▸ | TYK2 | P29597 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.48 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.45 |
| ▸ | PAK4 | O96013 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29540938 | 0.90 | JAK2 (0.60) | JAK2JAK1HDAC6HDAC1JAK3 | |
| SCHEMBL100638 | 0.90 | JAK2 (0.60) | JAK2JAK1HDAC6HDAC1JAK3 | |
| SCHEMBL17219905 | 0.85 | ALK (0.52) | JAK2JAK1JAK3TYK2ALK | |
| SCHEMBL101593 | 0.79 | JAK2 (0.62) | JAK2JAK1HDAC6HDAC1JAK3 | |
| SCHEMBL103224 | 0.78 | JAK2 (0.49) | JAK2JAK1HDAC6HDAC1JAK3 | |
| SCHEMBL27947529 | 0.76 | JAK2 (0.61) | JAK2JAK1JAK3TYK2ALK | |
| SCHEMBL13695723 | 0.76 | JAK2 (0.65) | JAK2JAK1HDAC6HDAC1JAK3 | |
| SCHEMBL2144942 | 0.76 | JAK2 (0.59) | JAK2JAK1HDAC6HDAC1JAK3 | |
| SCHEMBL101199 | 0.75 | JAK2 (0.54) | JAK2JAK1HDAC6HDAC1JAK3 | |
| SCHEMBL29540833 | 0.75 | JAK2 (0.54) | JAK2JAK1HDAC6HDAC1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3042655-A1 | JANUS KINASE INHIBITORS FOR TREATMENT OF DRY EYE AND OTHER EYE RELATED DISEASES | Incyte Holdings Corporation (US) | 2016-07-13 | — | — | EP | disclosed |