Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.51 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.51 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 10/20 | 0.45 |
| ▸ | JAK3 | P52333 | 6/20 | 0.45 |
| ▸ | JAK2 | O60674 | 11/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.42 |
| ▸ | CCNK | O75909 | 2/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL99415 | 0.90 | ALK (0.61) | ALKAURKBAURKAINCENPTPX2 | |
| SCHEMBL29540647 | 0.90 | ALK (0.61) | ALKAURKBAURKAINCENPTPX2 | |
| SCHEMBL17907476 | 0.85 | JAK2 (0.54) | ALKAURKBAURKAJAK1JAK3 | |
| Trifluoroacetic Acid SCHEMBL4089057 | 0.82 | ALK (0.53) | ALKAURKBAURKAINCENPTPX2 | |
| SCHEMBL101771 | 0.80 | AURKB (0.54) | ALKAURKBAURKAINCENPTPX2 | |
| SCHEMBL30009412 | 0.79 | AURKB (0.62) | ALKAURKBAURKAINCENPTPX2 | |
| SCHEMBL99373 | 0.79 | AURKB (0.62) | ALKAURKBAURKAINCENPTPX2 | |
| SCHEMBL101660 | 0.79 | GRM4 (0.70) | ALKAURKBAURKAINCENPTPX2 | |
| SCHEMBL16673732 | 0.79 | GRM4 (0.60) | ALKAURKBAURKAINCENPTPX2 | |
| SCHEMBL100283 | 0.77 | AURKB (0.59) | ALKAURKBAURKAINCENPTPX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343299-B1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE CORP (US) | 2015-11-04 | — | — | EP | claimed |