Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 17/20 | 0.48 |
| ▸ | JAK1 | P23458 | 15/20 | 0.48 |
| ▸ | JAK3 | P52333 | 10/20 | 0.48 |
| ▸ | TYK2 | P29597 | 6/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.46 |
| ▸ | PAK4 | O96013 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | LTK | P29376 | 2/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2440607 | 0.95 | TYRO3 (0.47) | TYRO3JAK2JAK1JAK3TYK2 | |
| SCHEMBL29540833 | 0.86 | JAK2 (0.54) | TYRO3JAK2JAK1JAK3TYK2 | |
| SCHEMBL101199 | 0.86 | JAK2 (0.54) | TYRO3JAK2JAK1JAK3TYK2 | |
| SCHEMBL3378110 | 0.84 | TYRO3 (0.51) | TYRO3JAK2JAK1JAK3TYK2 | |
| SCHEMBL101133 | 0.82 | TYRO3 (0.49) | TYRO3JAK2JAK1JAK3TYK2 | |
| SCHEMBL15267801 | 0.82 | JAK2 (0.56) | TYRO3JAK2JAK1JAK3TYK2 | |
| SCHEMBL2144942 | 0.81 | JAK2 (0.59) | TYRO3JAK2JAK1JAK3TYK2 | |
| Trifluoroacetic Acid SCHEMBL100175 | 0.81 | TYRO3 (0.55) | TYRO3JAK2JAK1JAK3TYK2 | |
| Trifluoroacetic Acid SCHEMBL98943 | 0.81 | TYRO3 (0.55) | TYRO3JAK2JAK1JAK3TYK2 | |
| Trifluoroacetic Acid SCHEMBL20512407 | 0.81 | TYRO3 (0.55) | TYRO3JAK2JAK1JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3042655-A1 | JANUS KINASE INHIBITORS FOR TREATMENT OF DRY EYE AND OTHER EYE RELATED DISEASES | Incyte Holdings Corporation (US) | 2016-07-13 | — | — | EP | disclosed |