Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 20/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL17907710 | 0.93 | ENPP2 (0.63) | ENPP2 | |
| SCHEMBL17907676 | 0.92 | ENPP2 (0.71) | ENPP2 | |
| SCHEMBL17907641 | 0.92 | ENPP2 (0.71) | ENPP2 | |
| Hydrochloric Acid SCHEMBL17907591 | 0.88 | ENPP2 (0.68) | ENPP2 | |
| SCHEMBL15418073 | 0.85 | ENPP2 (0.82) | ENPP2 | |
| SCHEMBL17907841 | 0.85 | ENPP2 (0.75) | ENPP2 | |
| SCHEMBL17907708 | 0.85 | ENPP2 (0.75) | ENPP2 | |
| Hydrochloric Acid SCHEMBL17907604 | 0.84 | ENPP2 (0.67) | ENPP2 | |
| SCHEMBL17907657 | 0.84 | ENPP2 (0.69) | ENPP2 | |
| SCHEMBL17907598 | 0.83 | ENPP2 (0.60) | ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2687531-B1 | TETRAHYDROCARBOLINE DERIVATIVE | ONO PHARMACEUTICAL CO (JP) | 2016-07-13 | — | — | EP | claimed |