Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 12/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17907966 | 0.89 | PTGDR2 (0.51) | PTGDR2AKR1C3TBXA2RAKR1C2CNR2 | |
| SCHEMBL17907993 | 0.85 | PTGDR2 (0.50) | PTGDR2TBXA2RPTGDR | |
| SCHEMBL17907926 | 0.84 | PTGDR2 (0.47) | PTGDR2AKR1C3TBXA2RAKR1C2PTGDR | |
| SCHEMBL17907960 | 0.83 | PTGDR2 (0.49) | PTGDR2AKR1C3TBXA2RCNR2PTGS2 | |
| SCHEMBL17907972 | 0.81 | PTGDR2 (0.52) | PTGDR2TBXA2RPTGDR | |
| SCHEMBL17907989 | 0.81 | PTGDR2 (0.52) | PTGDR2TBXA2RPTGDR | |
| SCHEMBL17908003 | 0.80 | PTGDR2 (0.61) | PTGDR2TBXA2RPTGDR | |
| SCHEMBL17907967 | 0.79 | PTGDR2 (0.59) | PTGDR2TBXA2RPTGDR | |
| SCHEMBL13278751 | 0.77 | PTGDR2 (0.59) | PTGDR2TBXA2RPTGDR | |
| SCHEMBL13278879 | 0.77 | PTGDR2 (0.59) | PTGDR2TBXA2RPTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697223-B1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-07-13 | — | — | EP | disclosed |