Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17913144 | 0.85 | PDE4A (0.59) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17913433 | 0.82 | CYP1A2 (0.43) | PDE4APDE4BPDE4CPDE4DCYP2A6 | |
| SCHEMBL8406889 | 0.82 | NQO1 (0.50) | ALDH1A1GFERPDE4APDE4BPDE4C | |
| SCHEMBL30725533 | 0.82 | NQO1 (0.50) | ALDH1A1GFERPDE4APDE4BPDE4C | |
| SCHEMBL2152147 | 0.80 | TTR (0.47) | ALDH1A1TTRTRPV4KMT2AMEN1 | |
| SCHEMBL905352 | 0.80 | TTR (0.51) | ALDH1A1TTRTRPV4KMT2AMEN1 | |
| SCHEMBL8141550 | 0.77 | CYP2A6 (0.43) | ALDH1A1CYP2A6TRPV4KMT2AMEN1 | |
| SCHEMBL8141580 | 0.77 | CYP2A6 (0.43) | ALDH1A1CYP2A6TRPV4KMT2AMEN1 | |
| SCHEMBL17913363 | 0.75 | CYP2A6 (0.42) | ALDH1A1TTRCYP2A6TRPV4KMT2A | |
| SCHEMBL17913342 | 0.75 | CYP2A6 (0.42) | ALDH1A1CYP2A6TRPV4KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016112088-A1 | ARYLOXYACETYLINDOLES AND ANALOGS AS ANTIBIOTIC TOLERANCE INHIBITORS | SPERO THERAPEUTICS, INC. (US) | 2016-07-14 | — | — | WO | disclosed |
| WO-2016112088-A1 | ARYLOXYACETYLINDOLES AND ANALOGS AS ANTIBIOTIC TOLERANCE INHIBITORS | SPERO THERAPEUTICS, INC. (US) | 2016-07-14 | — | — | WO | disclosed |