Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | PTGES2 | Q9H7Z7 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11313806 | 0.85 | MAPT (0.59) | TRPV4SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL6481702 | 0.85 | ERN1 (0.45) | TTRMAPTHTTGAATSHR | |
| SCHEMBL905352 | 0.83 | TTR (0.51) | TTRTRPV4SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL8151401 | 0.83 | TRPV4 (0.52) | TRPV4SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL1306371 | 0.82 | TRPV4 (0.46) | TRPV4SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL4422704 | 0.82 | TRPV4 (0.46) | TRPV4SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL7666763 | 0.82 | TRPV4 (0.50) | TRPV4SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL1679612 | 0.82 | PDCD1 (0.50) | TRPV4SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL25735778 | 0.82 | TRPV4 (0.46) | TRPV4SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL29825398 | 0.82 | PDCD1 (0.50) | TRPV4SLC6A4SLC6A2SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 112 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111303000-B | Monosubstituted or disubstituted indole derivatives as dengue virus replication inhibitors | 杨森制药公司 | 2023-11-28 | — | — | CN | claimed |
| EP-3896072-B1 | MONO- OR DI-SUBSTITUTED INDOLE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS | JANSSEN PHARMACEUTICALS INC (US) | 2022-11-16 | — | — | EP | claimed |
| EP-3896072-A1 | MONO- OR DI-SUBSTITUTED INDOLE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS | Janssen Pharmaceuticals, Inc. (US) | 2021-10-20 | — | — | EP | claimed |
| CN-107001264-B | Monosubstituted or disubstituted indole derivatives as inhibitors of dengue virus replication | 杨森制药公司 | 2021-06-15 | — | — | CN | claimed |
| US-5565602-A | REACTING A HYDROCARBYL CHLORIDE WITH A CARBONYL SULFIDE AND AMINE IN PRESENCE OF A BASIC CATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1996-10-15 | — | — | US | claimed |
| US-4248779-A | REACTING CARBONYL SULFIDE WITH A SECONDARY AMINE AND REACTING THE AMINE SALT WITH A HALOHYDROCARBON | IHARA CHEMICAL INDUSTRY COMPANY, LIMITED (JP) | 1981-02-03 | — | — | US | claimed |
| EP-4240331-B1 | SOLID FORMULATION | UNIV LEUVEN KATH (BE) | 2026-04-29 | — | — | EP | disclosed |
| US-20250281457-A1 | TREATMENT OR PREVENTION OF DENGUE VIRAL INFECTION | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2025-09-11 | — | — | US | disclosed |
| US-20250230127-A1 | MONO- OR DI-SUBSTITUTED INDOLE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS | JANSSEN PHARMACEUTICALS INC (US) | 2025-07-17 | — | — | US | disclosed |
| EP-4522163-A1 | TREATMENT OR PREVENTION OF DENGUE VIRAL INFECTION | Janssen Pharmaceuticals, Inc. (US) | 2025-03-19 | — | — | EP | disclosed |
| US-12172959-B2 | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors | Janssen Pharmaceuticals, Inc. (US) | 2024-12-24 | — | — | US | disclosed |
| CN-119173261-A | Treatment and/or prevention of dengue virus infection | 杨森制药公司 | 2024-12-20 | — | — | CN | disclosed |
| US-12054474-B2 | Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2024-08-06 | — | — | US | disclosed |
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |
| CN-1361775-A | Novel diphenyl-piperidine derivate | ASTRAZENECA UK LTD (GB) | 2002-07-31 | — | — | CN | disclosed |
| EP-1202984-A1 | NOVEL DIPHENYL-PIPERIDINE DERIVATE | AstraZeneca UK Limited (GB) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001005782-A1 | NOVEL DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LIMITED (GB) | 2001-01-25 | — | — | WO | disclosed |
| US-5565602-A | REACTING A HYDROCARBYL CHLORIDE WITH A CARBONYL SULFIDE AND AMINE IN PRESENCE OF A BASIC CATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1996-10-15 | — | — | US | disclosed |
| US-4248779-A | REACTING CARBONYL SULFIDE WITH A SECONDARY AMINE AND REACTING THE AMINE SALT WITH A HALOHYDROCARBON | IHARA CHEMICAL INDUSTRY COMPANY, LIMITED (JP) | 1981-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250281457-A1 | TREATMENT OR PREVENTION OF DENGUE VIRAL INFECTION | F3, FOXO3, FOXO1 | TTR 258/4885TRPV4 1723/4885SLC6A4 2328/4885 |
| US-12054474-B2 | Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases | PROKR1, GIPR, PROKR2 | TTR 2466/4885TRPV4 2095/4885SLC6A4 162/4885 |
| US-20250230127-A1 | MONO- OR DI-SUBSTITUTED INDOLE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS | IDO1, IDO2, IRF3 | TTR 2477/4885TRPV4 3145/4885SLC6A4 386/4885 |
| US-12172959-B2 | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors | IDO1, IDO2, IRF3 | TTR 2537/4885TRPV4 3117/4885SLC6A4 355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.