Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL897160 | 0.87 | CYP3A4 (0.34) | CYP3A4TOP2A | |
| SCHEMBL17627244 | 0.87 | CYP3A4 (0.34) | CYP3A4TOP2A | |
| SCHEMBL15659627 | 0.87 | CYP3A4 (0.34) | CYP3A4TOP2A | |
| SCHEMBL15659482 | 0.87 | CYP3A4 (0.34) | CYP3A4TOP2A | |
| SCHEMBL898414 | 0.87 | CYP3A4 (0.34) | CYP3A4TOP2A | |
| SCHEMBL6825515 | 0.87 | CYP3A4 (0.34) | CYP3A4TOP2A | |
| SCHEMBL8814583 | 0.85 | CA2 (0.33) | — | |
| SCHEMBL17913481 | 0.84 | CYP3A4 (0.31) | CYP3A4TOP2A | |
| SCHEMBL17790065 | 0.81 | CYP3A4 (0.32) | CYP3A4TOP2A | |
| SCHEMBL1703160 | 0.80 | CYP3A4 (0.34) | CYP3A4TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016112088-A1 | ARYLOXYACETYLINDOLES AND ANALOGS AS ANTIBIOTIC TOLERANCE INHIBITORS | SPERO THERAPEUTICS, INC. (US) | 2016-07-14 | — | — | WO | disclosed |