Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17913712 | 0.85 | KDM2B (0.35) | KDM2BMAPT | |
| SCHEMBL17913845 | 0.84 | USP30 (0.38) | MEN1ALDH1A1KMT2AMAPT | |
| SCHEMBL17913786 | 0.83 | KDM2B (0.36) | KDM2BMAPT | |
| SCHEMBL17913796 | 0.81 | KDM2B (0.34) | KDM2BHSD17B10MEN1KMT2AMAPT | |
| SCHEMBL28618199 | 0.79 | MAPT (0.33) | KDM2BMAPT | |
| SCHEMBL14699492 | 0.78 | KDM2B (0.30) | KDM2B | |
| SCHEMBL2997280 | 0.77 | MEN1 (0.38) | KDM2BHSD17B10MEN1ALDH1A1KMT2A | |
| SCHEMBL17913745 | 0.77 | KDM2B (0.31) | KDM2B | |
| SCHEMBL16411910 | 0.75 | PDK2 (0.39) | — | |
| SCHEMBL14305089 | 0.74 | TLR2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3242872-A1 | (PIPERIDIN-3-YL)(NAPHTHALEN-2-YL)METHANONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE HISTONE DEMETHYLASE KDM2B FOR THE TREATMENT OF CANCER | Genentech, Inc. (US) | 2017-11-15 | — | — | EP | disclosed |
| WO-2016112284-A1 | (PIPERIDIN-3-YL)(NAPHTHALEN-2-YL)METHANONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE HISTONE DEMETHYLASE KDM2B FOR THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2016-07-14 | — | — | WO | disclosed |