Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.67 |
| ▸ | JAK1 | P23458 | 11/20 | 0.67 |
| ▸ | EGFR | P00533 | 3/20 | 0.65 |
| ▸ | BTK | Q06187 | 3/20 | 0.65 |
| ▸ | CDK1 | P06493 | 5/20 | 0.64 |
| ▸ | CDK2 | P24941 | 5/20 | 0.64 |
| ▸ | SYK | P43405 | 4/20 | 0.64 |
| ▸ | CDC7 | O00311 | 1/20 | 0.64 |
| ▸ | PLK4 | O00444 | 1/20 | 0.64 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.64 |
| ▸ | AURKA | O14965 | 1/20 | 0.64 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.64 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.64 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.64 |
| ▸ | PAK4 | O96013 | 1/20 | 0.64 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.64 |
| ▸ | ABL1 | P00519 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17916035 | 0.89 | JAK1 (0.62) | JAK3JAK1EGFRBTKCDK1 | |
| SCHEMBL13166197 | 0.88 | JAK3 (0.71) | JAK3JAK1EGFRBTKCDK1 | |
| SCHEMBL12279008 | 0.88 | TNNI3K (0.57) | JAK3JAK1EGFRBTKSYK | |
| SCHEMBL270596 | 0.87 | JAK3 (0.64) | JAK3JAK1EGFRBTKCDK1 | |
| SCHEMBL10260564 | 0.87 | JAK3 (0.64) | JAK3JAK1EGFRBTKCDK1 | |
| SCHEMBL30459522 | 0.84 | JAK3 (0.60) | JAK3JAK1EGFRBTKCDK1 | |
| SCHEMBL17916014 | 0.84 | BRD4 (0.66) | JAK3JAK1EGFRBTKSYK | |
| SCHEMBL17915956 | 0.84 | BRD4 (0.66) | JAK3JAK1EGFRBTKCDK1 | |
| SCHEMBL12321387 | 0.83 | JAK3 (0.60) | JAK3JAK1EGFRBTKCDK1 | |
| SCHEMBL1474463 | 0.83 | JAK3 (0.65) | JAK3JAK1EGFRBTKCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951684-B1 | BI-ARYL META-PYRIMIDINE INHIBITORS OF KINASES | TARGEGEN INC (US) | 2016-07-13 | — | — | EP | disclosed |