Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CCNK | O75909 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15946692 | 0.88 | LRRK2 (0.62) | LRRK2SYKAURKACCNA2CDK2 | |
| SCHEMBL270219 | 0.84 | TP53 (0.43) | LRRK2TP53SYKAURKAMAPT | |
| SCHEMBL301971 | 0.84 | TP53 (0.43) | LRRK2TP53SYKAURKAMAPT | |
| SCHEMBL12279165 | 0.83 | TP53 (0.49) | NUDT1TP53MAPTSMN1; SMN2RAPGEF4 | |
| SCHEMBL17916066 | 0.82 | ULK1 (0.54) | LRRK2TP53SYKAURKAMAPT | |
| SCHEMBL17916008 | 0.82 | AURKA (0.50) | SYKAURKAMAPTCDK2CDK9 | |
| SCHEMBL264974 | 0.80 | TP53 (0.47) | LRRK2NUDT1TP53MAPTSMN1; SMN2 | |
| SCHEMBL15946683 | 0.78 | LRRK2 (0.46) | LRRK2SYKAURKACCNA2CDK2 | |
| SCHEMBL17916012 | 0.78 | AURKA (0.47) | TP53AURKAMAPTSMN1; SMN2NPC1 | |
| SCHEMBL17916010 | 0.77 | EGFR (0.49) | LRRK2SYKAURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951684-B1 | BI-ARYL META-PYRIMIDINE INHIBITORS OF KINASES | TARGEGEN INC (US) | 2016-07-13 | — | — | EP | disclosed |