Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.61 |
| ▸ | LYN | P07948 | 1/20 | 0.61 |
| ▸ | SRC | P12931 | 15/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 14/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 14/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.58 |
| ▸ | PRKDC | P78527 | 14/20 | 0.58 |
| ▸ | ABL1 | P00519 | 13/20 | 0.58 |
| ▸ | EGFR | P00533 | 13/20 | 0.58 |
| ▸ | HCK | P08631 | 13/20 | 0.58 |
| ▸ | KDR | P35968 | 13/20 | 0.58 |
| ▸ | MTOR | P42345 | 13/20 | 0.58 |
| ▸ | EPHB4 | P54760 | 12/20 | 0.58 |
| ▸ | PI4KB | Q9UBF8 | 11/20 | 0.58 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.52 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17713765 | 0.88 | BTK (0.80) | BTKLCKLYNSRCABL1 | |
| SCHEMBL1614098 | 0.88 | BTK (0.80) | BTKLCKLYNSRCABL1 | |
| SCHEMBL29611773 | 0.88 | BTK (0.80) | BTKLCKLYNSRCABL1 | |
| SCHEMBL1614096 | 0.88 | BTK (0.80) | BTKLCKLYNSRCABL1 | |
| Hydrochloric Acid SCHEMBL17713743 | 0.87 | BTK (0.78) | BTKLCKLYNSRCABL1 | |
| Hydrochloric Acid SCHEMBL17713741 | 0.87 | BTK (0.78) | BTKLCKLYNSRCABL1 | |
| Hydrochloric Acid SCHEMBL16931735 | 0.87 | BTK (0.78) | BTKLCKLYNSRCABL1 | |
| Hydrochloric Acid SCHEMBL16931734 | 0.87 | BTK (0.78) | BTKLCKLYNSRCABL1 | |
| SCHEMBL22625427 | 0.87 | EGFR (0.66) | BTKLCKLYNSRCPIK3CD | |
| SCHEMBL28402694 | 0.87 | PIK3CD (0.61) | BTKLCKLYNSRCPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2650294-B1 | Inhibitors of Bruton's Tyrosine Kinase | PHARMACYCLICS LLC (US) | 2016-07-20 | — | — | EP | disclosed |