Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 19/20 | 0.61 |
| ▸ | PIK3CA | P42336 | 19/20 | 0.61 |
| ▸ | PIK3CB | P42338 | 19/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 19/20 | 0.61 |
| ▸ | PRKDC | P78527 | 19/20 | 0.61 |
| ▸ | ABL1 | P00519 | 18/20 | 0.61 |
| ▸ | EGFR | P00533 | 18/20 | 0.61 |
| ▸ | HCK | P08631 | 18/20 | 0.61 |
| ▸ | SRC | P12931 | 18/20 | 0.61 |
| ▸ | KDR | P35968 | 18/20 | 0.61 |
| ▸ | MTOR | P42345 | 18/20 | 0.61 |
| ▸ | EPHB4 | P54760 | 17/20 | 0.61 |
| ▸ | PI4KB | Q9UBF8 | 12/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | BTK | Q06187 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28402696 | 1.00 | PIK3CD (0.61) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL22625427 | 0.89 | EGFR (0.66) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL14139056 | 0.89 | BTK (0.64) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL15613465 | 0.88 | PIK3CD (0.72) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL17928487 | 0.87 | BTK (0.61) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL27088080 | 0.86 | PIK3CD (0.70) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL17713765 | 0.85 | BTK (0.80) | ABL1EGFRHCKSRCKDR | |
| SCHEMBL1614098 | 0.85 | BTK (0.80) | ABL1EGFRHCKSRCKDR | |
| SCHEMBL18265743 | 0.85 | BTK (0.59) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL29611773 | 0.85 | BTK (0.80) | ABL1EGFRHCKSRCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107344940-B | BTK inhibitors and uses thereof | 广东东阳光药业有限公司 | 2020-04-21 | — | — | CN | disclosed |