Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.67 |
| ▸ | NPC1 | O15118 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | GRM5 | P41594 | 11/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | GCK | P35557 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1796062 | 0.88 | GRM5 (0.60) | RAB9ANPC1HPGDSMN1; SMN2GRM5 | |
| SCHEMBL1795321 | 0.88 | GRM5 (0.51) | RAB9ANPC1HPGDSMN1; SMN2GRM5 | |
| SCHEMBL1796318 | 0.85 | GRM5 (0.57) | RAB9ANPC1HPGDSMN1; SMN2GRM5 | |
| SCHEMBL1797501 | 0.84 | GCK (0.57) | RAB9ANPC1GRM5GCKKMT2A | |
| SCHEMBL1795595 | 0.83 | GRM5 (0.52) | RAB9ANPC1GRM5HTTGCK | |
| SCHEMBL1795807 | 0.82 | GCK (0.59) | RAB9ANPC1GRM5ALDH1A1GCK | |
| SCHEMBL1795533 | 0.82 | GRM5 (0.57) | RAB9ANPC1HPGDSMN1; SMN2GRM5 | |
| SCHEMBL1794221 | 0.82 | GRM5 (0.50) | RAB9ANPC1GRM5ALDH1A1GCK | |
| SCHEMBL1796144 | 0.82 | GRM5 (0.58) | RAB9ANPC1GRM5 | |
| SCHEMBL1794133 | 0.80 | GCK (0.56) | RAB9ANPC1HPGDSMN1; SMN2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | claimed |
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |