Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 13/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GCK | P35557 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1793607 | 0.88 | RAB9A (0.67) | GRM5NPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL1794221 | 0.85 | GRM5 (0.50) | GRM5NPC1RAB9AGCK | |
| SCHEMBL1797501 | 0.83 | GCK (0.57) | GRM5NPC1RAB9AGCK | |
| SCHEMBL4772141 | 0.79 | DHODH (0.49) | — | |
| SCHEMBL1795595 | 0.79 | GRM5 (0.52) | GRM5NPC1RAB9AGCK | |
| SCHEMBL1795807 | 0.78 | GCK (0.59) | GRM5NPC1RAB9AGCK | |
| SCHEMBL1795533 | 0.78 | GRM5 (0.57) | GRM5NPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL1796144 | 0.78 | GRM5 (0.58) | GRM5NPC1RAB9A | |
| SCHEMBL1798452 | 0.78 | GRM5 (0.52) | GRM5NPC1RAB9AGCK | |
| SCHEMBL1796062 | 0.78 | GRM5 (0.60) | GRM5NPC1HPGDRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | claimed |
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |