Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1794050 | 0.88 | GRM5 (0.44) | GRM5TLR7BACE1MAPK1 | |
| SCHEMBL1794079 | 0.88 | GRM5 (0.47) | GRM5CYP1A2CYP2C9CYP3A4TLR7 | |
| SCHEMBL1796064 | 0.85 | MEN1 (0.47) | GRM5CYP1A2CYP2C9CYP3A4KCNH2 | |
| SCHEMBL1795560 | 0.85 | GRM5 (0.53) | GRM5CYP1A2CYP2C9CYP3A4LMNA | |
| SCHEMBL1794864 | 0.84 | GRM5 (0.48) | GRM5CYP1A2TLR7MAPK8MAPK10 | |
| SCHEMBL1798409 | 0.83 | SMN1; SMN2 (0.49) | GRM5CYP1A2CYP2C9CYP3A4TLR7 | |
| SCHEMBL1796021 | 0.83 | GRM5 (0.54) | GRM5MAPT | |
| SCHEMBL1796498 | 0.81 | TLR7 (0.43) | GRM5CYP1A2CYP2C9CYP3A4TLR7 | |
| SCHEMBL1798493 | 0.81 | GRM5 (0.43) | GRM5 | |
| SCHEMBL1796217 | 0.80 | IRAK4 (0.47) | GRM5MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | claimed |
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |