Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPA | Q15257 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1794050 | 0.91 | GRM5 (0.44) | SMN1; SMN2GRM5KDM4ETLR7NPC1 | |
| SCHEMBL1796064 | 0.86 | MEN1 (0.47) | GRM5NPC1RAB9ACYP3A4MEN1 | |
| SCHEMBL1798493 | 0.86 | GRM5 (0.43) | SMN1; SMN2GRM5MMP13KMO | |
| SCHEMBL1796498 | 0.85 | TLR7 (0.43) | SMN1; SMN2GRM5KDM4ETLR7CYP3A4 | |
| SCHEMBL1795560 | 0.84 | GRM5 (0.53) | GRM5NPC1RAB9ACYP3A4MEN1 | |
| SCHEMBL1793808 | 0.83 | GRM5 (0.51) | GRM5TLR7CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL1794079 | 0.82 | GRM5 (0.47) | GRM5KDM4ETLR7CYP3A4CYP1A2 | |
| SCHEMBL1798486 | 0.82 | SMN1; SMN2 (0.47) | SMN1; SMN2ABL1GRM5ALDH1A1KDM4E | |
| SCHEMBL1794581 | 0.81 | CYP3A4 (0.57) | SMN1; SMN2GRM5ALDH1A1NPC1RAB9A | |
| SCHEMBL1794940 | 0.80 | NPC1 (0.51) | SMN1; SMN2GRM5ALDH1A1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | claimed |
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |