Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 8/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.46 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.46 |
| ▸ | GCK | P35557 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1796425 | 0.90 | SMARCA2 (0.57) | GRM5MAPTNPC1MEN1KMT2A | |
| SCHEMBL1794709 | 0.84 | GRM5 (0.53) | GRM5MAPTNPC1MEN1KMT2A | |
| SCHEMBL1797024 | 0.84 | GRM5 (0.54) | GRM5MAPTNPC1MEN1KMT2A | |
| SCHEMBL1796743 | 0.84 | GRM5 (0.63) | GRM5MAPTNPC1MEN1KMT2A | |
| SCHEMBL1796910 | 0.82 | GRM5 (0.52) | GRM5MAPTNPC1MEN1KMT2A | |
| SCHEMBL1797295 | 0.82 | GRM5 (0.53) | GRM5MAPTNPC1MEN1KMT2A | |
| SCHEMBL1797599 | 0.81 | ABL1 (0.53) | GRM5MAPTNPC1MEN1KMT2A | |
| SCHEMBL1796144 | 0.80 | GRM5 (0.58) | GRM5MAPTNPC1RAB9AKDM4E | |
| SCHEMBL1794766 | 0.79 | GRM5 (0.49) | GRM5MAPTNPC1MEN1KMT2A | |
| SCHEMBL1797917 | 0.77 | GRM5 (0.60) | GRM5MAPTNPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | claimed |
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |