Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | GRM5 | P41594 | 13/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1797179 | 0.84 | GRM5 (0.56) | NPC1RAB9AGRM5KDM4EHTT | |
| SCHEMBL1799227 | 0.84 | GRM5 (0.56) | NPC1RAB9AGRM5KDM4EHTT | |
| SCHEMBL7898441 | 0.84 | NPC1 (0.62) | NPC1RAB9AGRM5KDM4EMAPT | |
| SCHEMBL7903360 | 0.80 | GRM5 (0.57) | NPC1RAB9AGRM5KDM4EMAPT | |
| SCHEMBL13148030 | 0.80 | GRM5 (0.57) | NPC1RAB9AGRM5KDM4EMAPT | |
| SCHEMBL1795907 | 0.80 | GRM5 (0.57) | NPC1RAB9AGRM5KDM4EMAPT | |
| SCHEMBL1795993 | 0.79 | MAPT (0.42) | NPC1RAB9AGRM5KDM4EHTT | |
| SCHEMBL1793269 | 0.79 | GRM5 (0.56) | NPC1RAB9AGRM5KDM4EMAPT | |
| SCHEMBL1793897 | 0.78 | RAB9A (0.59) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL1797792 | 0.78 | GRM5 (0.57) | NPC1RAB9AGRM5KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |