Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.51 |
| ▸ | HTR3A | P46098 | 1/20 | 0.51 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.51 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL1794342 | 1.00 | CHRNA7 (0.51) | CHRNA7HTR3ACHRNB4CHRNA3CHRNB2 | |
| SCHEMBL926885 | 0.91 | CHRNA7 (0.60) | CHRNA7HTR3ACHRNB4CHRNA3CHRNB2 | |
| Fumaric Acid SCHEMBL15663041 | 0.80 | CHRNA7 (0.81) | CHRNA7HTR3ACHRNB4CHRNA3 | |
| Fumaric Acid SCHEMBL15663039 | 0.80 | CHRNA7 (0.81) | CHRNA7HTR3ACHRNB4CHRNA3 | |
| SCHEMBL928225 | 0.77 | CHRNA7 (0.59) | CHRNA7HTR3ACHRNB4CHRNA3CHRNB2 | |
| Fumaric Acid SCHEMBL928618 | 0.76 | CHRNA7 (0.46) | CHRNA7HTR3ACHRNB4CHRNA3CHRNB2 | |
| Fumaric Acid SCHEMBL928619 | 0.76 | CHRNA7 (0.46) | CHRNA7HTR3ACHRNB4CHRNA3CHRNB2 | |
| SCHEMBL1752927 | 0.73 | HRH4 (0.51) | HTR3A | |
| SCHEMBL1752966 | 0.72 | NEK2 (0.55) | — | |
| SCHEMBL1752990 | 0.70 | KMT2A (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2316836-A1 | Substituted diazabicycloalkane derivatives as ligands at alpha 7 nicotinic acetylcholine receptors | Abbott Laboratories (US) | 2011-05-04 | — | — | EP | disclosed |