Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 4/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17941882 | 0.89 | CSNK2A1 (0.49) | CSNK2A1KDM4EHSD17B10PABPC1CASP1 | |
| SCHEMBL17941964 | 0.83 | NAMPT (0.46) | CSNK2A1KDM4EHSD17B10PABPC1CASP1 | |
| SCHEMBL17941888 | 0.78 | TNKS (0.51) | CSNK2A1KDM4EHSD17B10PABPC1CASP1 | |
| SCHEMBL16446539 | 0.76 | PDE4B (0.40) | KDM4EHSD17B10PDE4BPDE4DMAPT | |
| SCHEMBL15723560 | 0.75 | DHFR (0.50) | CSNK2A1KDM4EHSD17B10PABPC1CASP1 | |
| SCHEMBL17941957 | 0.74 | CSNK2A2 (0.47) | KDM4EHSD17B10CSNK2A2CSNK2BNAMPT | |
| SCHEMBL29893824 | 0.71 | CSNK2A1 (0.53) | CSNK2A1KDM4EHSD17B10CSNK2A2CSNK2B | |
| SCHEMBL20504366 | 0.71 | TP53 (0.55) | CSNK2A1KDM4EHSD17B10CSNK2A2CSNK2B | |
| SCHEMBL25894686 | 0.71 | CSNK2A1 (0.53) | CSNK2A1KDM4EHSD17B10CSNK2A2CSNK2B | |
| SCHEMBL29893311 | 0.71 | KDM4E (0.44) | CSNK2A1KDM4EHSD17B10CSNK2A2CSNK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016118565-A1 | QUINAZOLINE AND QUINOLINE COMPOUNDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2016-07-28 | — | — | WO | disclosed |