Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.52 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.52 |
| ▸ | CDK8 | P49336 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 2/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | PRKCG | P05129 | 1/20 | 0.50 |
| ▸ | INSR | P06213 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | FES | P07332 | 1/20 | 0.50 |
| ▸ | IGF1R | P08069 | 1/20 | 0.50 |
| ▸ | ROS1 | P08922 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.50 |
| ▸ | FER | P16591 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17951910 | 0.90 | NTRK1 (0.47) | NTRK1MAPK1 | |
| SCHEMBL19351251 | 0.82 | AXL (0.61) | AXLTNIKCDK8JAK2PLK4 | |
| SCHEMBL19068211 | 0.81 | AXL (0.59) | AXLTNIKCDK8JAK2PLK4 | |
| SCHEMBL17951906 | 0.78 | AXL (0.53) | AXLTNIKCDK8JAK2PLK4 | |
| SCHEMBL17939377 | 0.78 | JAK3 (0.51) | AXLTNIKCDK8JAK2JAK3 | |
| SCHEMBL17939379 | 0.78 | JAK3 (0.51) | AXLTNIKCDK8JAK2JAK3 | |
| SCHEMBL17939436 | 0.78 | JAK3 (0.51) | AXLTNIKCDK8JAK2JAK3 | |
| SCHEMBL17939012 | 0.76 | JAK3 (0.50) | AXLTNIKCDK8JAK2PLK4 | |
| SCHEMBL17939014 | 0.76 | JAK3 (0.50) | AXLTNIKCDK8JAK2PLK4 | |
| SCHEMBL17939567 | 0.76 | JAK3 (0.50) | AXLTNIKCDK8JAK2PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016118951-A2 | HETEROCYCLIC ITK INHIBITORS FOR TREATING INFLAMMATION AND CANCER | CONFLUENCE LIFE SCIENCES, INC. (US) | 2016-07-28 | — | — | WO | disclosed |