SCHEMBL17952686

SCHEMBL17952686

N#Cc1cccc(C#N)c1-c1ccccc1N1c2ccccc2Oc2ccccc21

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 1/20 0.39
TRPA1 O75762 2/20 0.36
KDM4E B2RXH2 1/20 0.35
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HIF1A Q16665 1/20 0.33
P2RX4 Q99571 1/20 0.33
SETD7 Q8WTS6 1/20 0.33
ESR2 Q92731 1/20 0.33
NOTUM Q6P988 1/20 0.33
HTR1A P08908 1/20 0.33
DRD2 P14416 1/20 0.33
LMNA P02545 1/20 0.33
CYP1A2 P05177 1/20 0.33
MAPT P10636 1/20 0.33
CYP2C9 P11712 1/20 0.33
MAPK1 P28482 1/20 0.33
CASP1 P29466 1/20 0.33
CYP2C19 P33261 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17954881 0.89 PDK2 (0.33) PDK2TRPA1KDM4EMEN1KMT2A
SCHEMBL20277158 0.89 PDK2 (0.38) PDK2TRPA1KDM4EMEN1KMT2A
SCHEMBL17954901 0.87 ESR2 (0.39) TRPA1KDM4EP2RX4ESR2MAPK1
SCHEMBL20277003 0.87 TRPA1 (0.38) PDK2TRPA1KDM4EMEN1KMT2A
SCHEMBL17949614 0.86 ESR2 (0.38) TRPA1KDM4EP2RX4ESR2KCNN4
SCHEMBL17954708 0.85 PDK2 (0.34) PDK2TRPA1KDM4EMEN1KMT2A
SCHEMBL17954984 0.84 MAPKAPK2 (0.35) KDM4EMEN1KMT2ASMN1; SMN2HIF1A
SCHEMBL17952692 0.84 SMN1; SMN2 (0.40) PDK2TRPA1KDM4ESMN1; SMN2HIF1A
SCHEMBL17949598 0.83 ESR2 (0.50) TRPA1ESR2CYP1A2MAPK1KCNN4
SCHEMBL17948421 0.80 ESR2 (0.36) TRPA1KDM4EP2RX4ESR2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016116504-A1 ORGANIC MOLECULES FOR USE IN OPTOELECTRONIC COMPONENTS CYNORA GMBH (DE) 2016-07-28 WO disclosed
WO-2016116508-A1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC COMPONENTS CYNORA GMBH (DE) 2016-07-28 WO disclosed