Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 9/20 | 0.50 |
| ▸ | HTR1A | P08908 | 8/20 | 0.50 |
| ▸ | HTR2C | P28335 | 8/20 | 0.49 |
| ▸ | HTR2B | P41595 | 8/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | BCL9 | O00512 | 3/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17955441 | 1.00 | SLC6A2 (0.50) | SLC6A2HTR1AHTR2CHTR2BSLC6A3 | |
| SCHEMBL17955423 | 0.92 | HTR1A (0.48) | SLC6A2HTR1AHTR2CHTR2BSLC6A3 | |
| SCHEMBL3113653 | 0.89 | HTR2C (0.52) | SLC6A2HTR1AHTR2CHTR2BSLC6A3 | |
| SCHEMBL19618927 | 0.82 | HTR1A (0.55) | SLC6A2HTR1AHTR2CHTR2BSLC6A3 | |
| SCHEMBL13034284 | 0.82 | HTR1A (0.55) | SLC6A2HTR1AHTR2CHTR2BSLC6A3 | |
| Hydrochloric Acid SCHEMBL3107935 | 0.81 | HTR1A (0.54) | SLC6A2HTR1AHTR2CHTR2BSLC6A3 | |
| SCHEMBL3880092 | 0.81 | SLC6A2 (0.54) | SLC6A2HTR1AHTR2CHTR2BSLC6A3 | |
| SCHEMBL15062008 | 0.81 | HTR2C (0.54) | SLC6A2HTR1AHTR2CHTR2BSLC6A3 | |
| SCHEMBL2944352 | 0.81 | SLC6A2 (0.54) | SLC6A2HTR1AHTR2CHTR2BSLC6A3 | |
| SCHEMBL15076157 | 0.81 | HTR2C (0.54) | SLC6A2HTR1AHTR2CHTR2BSLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9403835-B2 | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators | ARES TRADING S.A. (CH) | 2016-08-02 | — | — | US | disclosed |
| US-9403835-B2 | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators | ARES TRADING S.A. (CH) | 2016-08-02 | — | — | US | disclosed |