⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18067 | 1.00 | — | — | |
| SCHEMBL29516 | 0.89 | GCKR (0.30) | — | |
| SCHEMBL16994 | 0.89 | GCKR (0.30) | — | |
| SCHEMBL17655 | 0.89 | GCKR (0.30) | — | |
| SCHEMBL17203 | 0.88 | — | — | |
| SCHEMBL17549 | 0.85 | HSD11B1 (0.32) | — | |
| SCHEMBL17915 | 0.85 | HSD11B1 (0.32) | — | |
| SCHEMBL16903 | 0.85 | HSD11B1 (0.32) | — | |
| SCHEMBL17114 | 0.79 | GCKR (0.38) | — | |
| SCHEMBL16318 | 0.79 | GCKR (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609081-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | Amgen Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |