Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.51 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.44 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1795839 | 0.90 | GRM5 (0.52) | GRM5SORT1HDAC4SMARCA2SMARCA4 | |
| SCHEMBL1792454 | 0.87 | HDAC4 (0.46) | GRM5HDAC4 | |
| SCHEMBL1797543 | 0.83 | GRM5 (0.49) | GRM5SORT1HDAC4SMARCA2SMARCA4 | |
| SCHEMBL1794913 | 0.82 | GRM5 (0.51) | GRM5SORT1 | |
| SCHEMBL1795233 | 0.81 | GRM5 (0.56) | GRM5SORT1HDAC4SMARCA2SMARCA4 | |
| SCHEMBL1794085 | 0.79 | GRM5 (0.54) | GRM5SORT1HDAC4SMARCA2SMARCA4 | |
| SCHEMBL1793853 | 0.74 | CYP1A2 (0.50) | GRM5SORT1HDAC4SMARCA2SMARCA4 | |
| SCHEMBL1793676 | 0.74 | MAPT (0.51) | GRM5MEN1KMT2A | |
| SCHEMBL1797125 | 0.74 | GRM5 (0.49) | GRM5 | |
| SCHEMBL1795369 | 0.73 | GRM5 (0.41) | GRM5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |