Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1795370 | 0.83 | NPC1 (0.47) | GRM5NPC1RAB9AADORA2AKDM4E | |
| SCHEMBL1797965 | 0.82 | GRM5 (0.51) | GRM5NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL1797678 | 0.80 | GRM5 (0.55) | GRM5NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL1794913 | 0.78 | GRM5 (0.51) | GRM5ADORA2ALMNA | |
| SCHEMBL1795369 | 0.76 | GRM5 (0.41) | GRM5NPC1RAB9AADORA2AKDM4E | |
| SCHEMBL1794352 | 0.76 | CYP1A2 (0.47) | GRM5NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL1794198 | 0.74 | GRM5 (0.49) | GRM5NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL943765 | 0.74 | NPC1 (0.56) | GRM5NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL1796392 | 0.74 | GRM5 (0.52) | GRM5NPC1RAB9AMAPK7HPGDS | |
| SCHEMBL1795702 | 0.74 | GRM5 (0.51) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987003-A1 | PYRIDINE-2-CARBOXAMIDE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-11-05 | — | — | EP | claimed |
| WO-2007093542-A1 | PYRIDINE-2-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-23 | — | — | WO | claimed |
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |
| EP-1987003-A1 | PYRIDINE-2-CARBOXAMIDE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007093542-A1 | PYRIDINE-2-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-23 | — | — | WO | disclosed |